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KMID : 1134820160450020293
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 2 p.293 ~ p.297
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Inhibitory Effects of Transglycoslyation Products of Soy Isoflavones on Cholesterol Biosynthesis
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Yoo Lang-Kuk
Choi Seung-Jun
Moon Tae-Wha
Shim Jae-Hoon
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Abstract
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Hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) is the rate-limiting enzyme in biosynthesis of cholesterol in animals. In this study, inhibitory effects of isoflavone glycosides on HMG-CoA reductase were investigated. At sample concentration of 100 μM, genistein-7-O-triglucoside (G2-genistin) inhibited HMG-CoA reductase activity by approximately 18%, whereas daidzein-7-O-triglucoside had no inhibitory effect. In the kinetic experiments with Syrian hamster HMG-CoA reductase, G2-genistin showed inhibitory efficacy with an invariable Vmax value, suggesting that G2-genistin works as a competitive inhibitor of HMG-CoA reductase and has potential for hypocholesterolemic action through direct regulation of HMG-CoA reductase.
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KEYWORD
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soybean, isoflavone, isoflavone glycoside, HMG-CoA reductase, cholesterol biosynthesis
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